Serological evidence was used to confirm an outbreak of Akabane diseas
e in cattle in the Turkish Province of Aydin in 1980. Thereafter, seru
m collections from the Middle East were screened for the presence of n
eutralizing antibodies to Akabane virus. The results indicate that the
virus was present in a number of provinces on the south Turkish coast
in 1979 and 1980 but that it probably did not persist into 1981; the
virus had also been present on Cyprus in 1980 and on at least one prev
ious occasion. There was also evidence of limited virus transmission i
n the Orontes river valley in Syria in 1979 and less precise evidence
to show that occasional infection occurred in the lower Jordan river v
alley. The failure of Akabane virus to persist in southern Turkey for
more than two years indicates that this area is open to epidemic rathe
r than endemic infection. The presence of neutralizing antibodies in t
he eastern Turkish Provinces of Gaziantep and Diyarbakir suggests that
this might be the route whereby Akabane virus occasionally invades th
e Middle East region.