Kk. Anand et al., HEPATOPROTECTIVE STUDIES OF A FRACTION FROM THE FRUITS OF TERMINALIA-BELERICA ROXB ON EXPERIMENTAL LIVER-INJURY IN RODENTS, PTR. Phytotherapy research, 8(5), 1994, pp. 287-292
The effects of an orally administered fraction (TB5) from the fruits o
f Terminalia belerica in experimental liver injury induced by carbon t
etrachloride (CCl4) were studied. Hexobarbitone-induced sleep, zoxazol
amine-induced paralysis, transaminases, bilirubin, total protein in se
rum and microsomal lipid peroxidation and triglycerides in liver were
used as indices of liver injury. A significant hepatoprotective effect
was observed as evident from shortened hexobarbitone 'sleep time' and
zoxazolamine 'paralysis time' when compared with CCl4 alone. Pre- and
post-treatment of TB5 reduced, in a dose dependent manner, the elevat
ed levels of serum tranaminases and bilirubin in rats, thus demonstrat
ing its effect both as a prophylactic and curative. Its protective eff
ects on microsomal lipid peroxidation and triglycerides in liver sugge
st a restorative effect in the process of CCl4-induced liver damage. T
B5 did not show any signs of toxicity up to oral doses of 3.2 g/kg in
mice.