KROMOSCOPIC(TM) ANALYSIS - A POSSIBLE ALTERNATIVE TO SPECTROSCOPIC ANALYSIS FOR NONINVASIVE MEASUREMENT OF ANALYTES IN-VIVO

Light that penetrates scattering media shows nonlinearities that mask the broad and shallow perturbations made by trace analytes on the back ground illuminant spectrum. Narrow-band spectroscopic decomposition an d deconvolution of such weak bands is a formidable analytical task tha t pushes the fundamentally linear spectroscopic method beyond practica l limits. Kromoscopy(TM) is a high-dimensional analog of human color p erception; it has broad-band spectrally overlapping detectors similar to those of the visual system, but in the infrared. Analyte bands are integrated fully in two or more detectors with different relative weig htings. As in color vision, the analyte information is coded in the di rect correlations between detector signals, which individually have hi gher signal-to-noise ratios than their spectroscopic counterparts. Our Kromoscopic instrument responds directly to glucose in aqueous soluti on, is not affected by temperature disturbances, and is fast enough to measure physiologically induced Kromoscopic changes in the arterial p ulse waveform with high precision.