RENAL MICROANGIOPATHY IN THE PRIMARY ANTIPHOSPHOLIPID SYNDROME - A CASE-REPORT WITH LITERATURE-REVIEW

We report the case of a 52-year-old male patient with recurrent thromb osis from 'primary antiphospholipid syndrome' who developed renal micr oangiopathy. Despite anticoagulant therapy with coumadin, serum creati nine progressively increased from 398 to 592 mu mol/l and platelets de creased to 43,000. The patient responded to high-dose methylprednisolo ne and aspirin and the renal function improved. A review of the litera ture disclosed 4 other cases of association between primary antiphosph olipid syndrome and renal microangiopathy. The clinical characteristic s of these cases are discussed.