COMPATIBILITY AND STABILITY OF ONDANSETRON HYDROCHLORIDE WITH MORPHINE-SULFATE AND WITH HYDROMORPHONE HYDROCHLORIDE IN 0.9-PERCENT SODIUM-CHLORIDE INJECTION AT 4-DEGREES-C, 22-DEGREES-C, AND 32-DEGREES-C

The physical compatibility and chemical stability of ondansetron hydro chloride 0.1 and 1 mg/mL with morphine sulfate 1 mg/mL and with hydrom orphone hydrochloride 0.5 mg/mL in 0.9% sodium chloride injection were studied. Test solutions of the drugs in 0.9% sodium chloride injectio n were prepared in triplicate and stored at 4, 22, and 32 degrees C. S amples were removed immediately and at various time points over 31 day s and stored at -70 degrees C until analyzed. Physical compatibility w as assessed visually and by measuring turbidity with a color-correctin g turbidimeter and particle content with a light-obscuration particle sizer and counter. Chemical stability was determined by measuring the concentration of each drug in duplicate with stability-indicating high -performance liquid chromatography. There were no visual or subvisual changes in turbidity or particle content in any of the test solutions at any of the time points. There was little or no loss of any of the d rugs. When admixed in 0.9% sodium chloride injection, ondansetron hydr ochloride 0.1 and 1 mg/mL plus morphine sulfate 1 mg/mL or hydromorpho ne hydrochloride 0.5 mg/mL were compatible and stable for at least 7 d ays at 32 degrees C and for at least 31 days at 4 and 22 degrees C.