ANALYSIS OF THE MUTAGENIC AND TERATOGENIC EFFECTS OF GRISEOFULVIN IN THE MUTAGEN-SENSITIVE LINE MUS(2)201G1 OF DROSOPHILA-MELANOGASTER

The mutagenic effect of griseofulvin was demonstrated in a wing somati c mosaicism test (SMART) in different Drosophila lines. The mutagenic effect of this agent is accompanied by a pronounced toxic effect on Dr osophila larvae and by a teratogenic effect, which is manifested in th e reduction of ommatidia, phenocopying the mutation ey (eyeless -4:2.0 ). A relationship was shown between the level of the phenocopies and t he dose of griseofulvin (GF), the genotypes of the treated larvae, the interval and duration of GF exposure, and also sexual differences. Th e lowest level of phenocopies is recorded for the line developed on th e basis of the mutagen-sensitive mutation mus(2)201G1, which blocks ex cision repair.