ANALYSIS OF THE MUTAGENIC AND TERATOGENIC EFFECTS OF GRISEOFULVIN IN THE MUTAGEN-SENSITIVE LINE MUS(2)201G1 OF DROSOPHILA-MELANOGASTER

Citation
Oa. Isaenko et al., ANALYSIS OF THE MUTAGENIC AND TERATOGENIC EFFECTS OF GRISEOFULVIN IN THE MUTAGEN-SENSITIVE LINE MUS(2)201G1 OF DROSOPHILA-MELANOGASTER, Genetika, 30(6), 1994, pp. 796-800
Citations number
13
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
00166758
Volume
30
Issue
6
Year of publication
1994
Pages
796 - 800
Database
ISI
SICI code
0016-6758(1994)30:6<796:AOTMAT>2.0.ZU;2-R
Abstract
The mutagenic effect of griseofulvin was demonstrated in a wing somati c mosaicism test (SMART) in different Drosophila lines. The mutagenic effect of this agent is accompanied by a pronounced toxic effect on Dr osophila larvae and by a teratogenic effect, which is manifested in th e reduction of ommatidia, phenocopying the mutation ey (eyeless -4:2.0 ). A relationship was shown between the level of the phenocopies and t he dose of griseofulvin (GF), the genotypes of the treated larvae, the interval and duration of GF exposure, and also sexual differences. Th e lowest level of phenocopies is recorded for the line developed on th e basis of the mutagen-sensitive mutation mus(2)201G1, which blocks ex cision repair.