M. Vandecasteele et al., HYPERCALCEMIA, MONOCLONAL PROTEIN, AND OSTEOLYTIC BONE-LESIONS IN CHRONIC LYMPHOCYTIC-LEUKEMIA, Annals of hematology, 69(2), 1994, pp. 79-80
We describe a patient with a long history of typical chronic lymphocyt
ic leukemia (CLL) who developed hypercalcemia, osteolytic bone lesions
, and a monoclonal protein, all features of a secretory plasma cell di
sorder. These features in CLL have been reported in only four previous
cases. The hypercalcemia in our patient is felt to result from an inc
rease in the osteoclastic process.