ACQUIRED VON-WILLEBRAND DISEASE AS A CAUSE OF RECURRENT MUCOCUTANEOUSBLEEDING IN PRIMARY THROMBOCYTHEMIA - RELATIONSHIP WITH PLATELET COUNT

We present a 4-year follow-up of a 42-year-old patient with primary th rombocythemia whose clinical course was complicated by two major mucoc utaneous bleeding episodes. On both occasions an acquired functional v on Willebrand factor deficiency was demonstrated. In contrast to what is reported in the literature, an inverse relationship between platele t number and plasma high-molecular-weight multimers of von Willebrand factor was established.