MODELING OF RELEASE KINETICS OF DRUGS FROM IRRADIATED NACMC MATRIX

The purpose of this work was to study the release kinetics of an activ e substance from a solid structure after irradiation, in order to exam ine the possible modifications induced in drug delivery. This method o f sterilization seems to be convenient for obtaining sterile parentera l or ophthalmic dosage forms. The problem of controlled release of dru g from a polymeric matrix is very complex. In this case, the phenomena take place under transient diffusion and the transfer of matter is co ntrolled by diffusion. The modelling of the process has been successfu lly tested, by comparing experimental and calculated values. The diffu sivity of the liquid through the various dosage forms increases signif icantly with irradiation.