GLUCOSE-INDUCED THERMOGENESIS IN POSTOBESE WOMEN WHO HAVE UNDERGONE BILIOPANCREATIC DIVERSION

We evaluated the metabolic response to a standard (75-g) oral-glucose- tolerance test (OGTT) in eight post obese women (PO) who underwent bil iopancreatic diversion and in eight healthy control women (C). All sub jects had been weight-stable for greater than or equal to 2 y. Blood s amples for glucose, insulin, C-peptide, and nonesterified free fatty a cids were taken at baseline and during 180 min after the glucose load. Plasma glucose and insulin concentrations at baseline and during the OGTT were similar in the two groups, suggesting the absence of an insu lin-resistant state in the PO. Continuous indirect calorimetry was per formed throughout the test. Glucose-induced thermogenesis (GIT) was hi gher in PO than in C (8.6 +/- 2.6 vs 4.3 +/- 1.9%; P < 0.01). These da ta indicate that GIT and insulin-glucose metabolism are not impaired i n postobese patients when a near ideal body weight is reached and main tained after weight loss; this suggests that thermogenic deficiencies and hyperinsulinemia-insulin resistance are alterations secondary to o besity.