Wj. Burtis et al., DIETARY HYPERCALCIURIA IN PATIENTS WITH CALCIUM-OXALATE KIDNEY-STONES, The American journal of clinical nutrition, 60(3), 1994, pp. 424-429
The relative importance of dietary factors in causing hypercalciuria w
as assessed in 282 unselected patients with calcium oxalate kidney sto
nes. The 124 patients found to be hypercalciuric on either their custo
mary free diet or on a 25-mmol (1000-mg) calcium defined diet (or both
), were classified according to their pattern of calcium excretion on
the two diets. Unexpectedly, about half of the patients who were hyper
calciuric on their free diet exhibited a calcium excretion that fell m
arkedly or normalized on the high-calcium defined diet. These patients
were defined as having dietary hypercalciuria. For all 282 patients,
multiple-regression analysis suggested that dietary sodium was at leas
t as important as was dietary calcium, and more important than dietary
protein, carbohydrate, phosphorus, purine, or oxalate, in contributin
g to calcium excretion on the free diet. Among the 124 hypercalciuric
patients, urinary calcium excretion increased by 0.0193 mmol (0.77 mg)
per mmol sodium excretion. Dietary habits, particularly a high sodium
intake, may commonly contribute to hypercalciuria in patients with ca
lcium oxalate stones.