15-DEOXYSPERGUALIN CONTROLS CYCLOSPORINE-RESISTANT AND STEROID-RESISTANT INTESTINAL ACUTE GRAFT-VERSUS-HOST-DISEASE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION

Authors
KASAI M HIGA T NAOHARA T MASAUZI N WATANABE M MATSUURA A OHIZUMI H TANAKA J MORII K KIYAMA Y SAITOH M HASHINO S KOBAYASHI H KOBAYASHI M IMAMURA M SAKURADA K MIYAZAKI T
Citation
M. Kasai et al., 15-DEOXYSPERGUALIN CONTROLS CYCLOSPORINE-RESISTANT AND STEROID-RESISTANT INTESTINAL ACUTE GRAFT-VERSUS-HOST-DISEASE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION, Bone marrow transplantation, 14(2), 1994, pp. 315-317
Citations number
10
Categorie Soggetti
Hematology,Oncology,Immunology
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
14
Issue
2
Year of publication
1994
Pages
315 - 317
Database
ISI
SICI code
0268-3369(1994)14:2<315:1CCAS>2.0.ZU;2-F
Abstract
We report a case of cyclosporin- and methylprednisolone-resistant inte stinal acute graft-versus-host disease (GVHD) after allogeneic bone ma rrow transplantation which responded to a new immunosuppressant, 15-de oxyspergualin (DSG). Endoscopy showed lymphoid hyperplasia with CD3(+) , CD4(+), CD8(-) lymphocyte infiltration into the submucosa of the jej unum and colon. DSG effectively suppressed this intestinal acute GVHD.