POSSIBLE MECHANISMS OF CHROMOSOMAL-ABERRA TIONS .7. COMPARATIVE DYNAMICS OF SISTER-CHROMATID DISJUNCTION AND REALIZATION OF RADIATION-INDUCED CHROMOSOMAL-ABERRATIONS DURING MITOSIS

Authors
LEBEDEVA LI AKHMAMETEVA EM
Citation
Li. Lebedeva et Em. Akhmameteva, POSSIBLE MECHANISMS OF CHROMOSOMAL-ABERRA TIONS .7. COMPARATIVE DYNAMICS OF SISTER-CHROMATID DISJUNCTION AND REALIZATION OF RADIATION-INDUCED CHROMOSOMAL-ABERRATIONS DURING MITOSIS, Genetika, 30(5), 1994, pp. 644-648
Citations number
11
Categorie Soggetti
Genetics & Heredity
Journal title
Genetika → ACNP
ISSN journal
00166758
Volume
30
Issue
5
Year of publication
1994
Pages
644 - 648
Database
ISI
SICI code
0016-6758(1994)30:5<644:PMOCT.>2.0.ZU;2-W
Abstract
An increase in radiation-induced chromosomal aberrations during c-meta phase sister chromatid disjunction was demonstrated in murine bone mar row cells exposed to a total gamma-irradiation at 0.5 and 1.5 Gy. Caff eine (Cf) treatment during mitosis partially suppressed of the chromat id disjunction rate and increased the number of radiation-induced aber rations in this mitosis. Nalidixic acid (NA) treatment of c-metaphase cells completely suppressed chromatid disjunction and the realization of induced aberrations. Topoisomerase 2 was assumed to be involved dur ing mitosis in both processes.