THE STUDY OF GENETIC-MARKERS OF RUSSIANS AND GERMANS WITHIN THE FRAMEWORK OF A JOINT RUSSIAN GERMAN RESEARCH-PROJECT

Information of the distribution of gene frequencies of some serum prot eins and erythrocyte enzymes in four Russian populations and one Germa n population was obtained during a joint population genetic research p roject of Institute of Clinical Genetics of the Medical Genetic Scient ific Center, Russian Academy of Medical Sciences, and the Institute of Forensic Medicine, Medical Academy of Magdeburg. The study of polymor phism at the PLG, AHS, FXIIIB, and ITI loci in populations of Russia w as performed for the first time. The following values of gene frequenc ies were estimated for Germans of Magdeburg: Gc - 1S = 0.6092; *1F = 0.1367; 2 = 0.2541; Tf - *B = 0.0068; *C1 = 0.7654; *C2 = 0.1561; *C3 = 0.0717; PI - M1 = 0.7096; *M2 = 0.1464; *M3 = 0.1128; *S = 0.0192; Z = 0.0120; PLG - *A V 0.7116; *B = 0.2853; *V = 0.0031; AHS - 0.671 0; 2 = 0.3264; *V = 0.0026; FXIIIB - *1 = 0.7610; *2 = 0.0721; *3 = 0 .1651; V = 0.0018; ITI - *1 = 0.5899; *2 = 0.4065; *V = 0.0036; Hp - 1 = 0.4109; *2 = 0.5891; PGM1 -1A = 0.6463; *2A = 0.1816; *1B = 0.127 2; 2B = 0.0449; ACP1 - *A = 0.3427; *B = 0.5972; and *C = 0.0601. The mean frequencies of the same genes for Russians are: Gc - 1S = 0.588 9; 1F = 0.1231; *2 = 02880; Tf - *B = 0.0044; *C1 = 0.8242; *C2 = 0.1 381; C3 = 0.0260; *D = 0.0073; PI - *M1 = 0.7460; *M2 = 0.1552; *M3 = 0.0862; S = 0.0066; *Z = 0.0060; PLG - *A = 0.7239; *B = 0.2719; *V = 0.0042; AHS - 1 = 0.6518; *2 = 0.3431; *V = 0.0051; FXIIIB - *1 = 0 .6774; 2 = 0.0879; *3 = 0.2347; ITI - *1 = 0.6257; *2 = 0.3687; *V = 0.0056; Hp - 1 = 0.3186; *2 = 0.6814; PGM1 - *1A = 0.5606; *2A = 0.26 31; 1B = 0.1038; *2B = 0.0725; ACP1 - *A = 0.3112; *B = 0.6317; and * C = 0.0571. A comparison of populations of German and Slavic language groups was performed using data on the distribution of the studied pol ymorphisms in Europe. The Germanic language populations were highly ho mogeneous in genetic matter. The studied Russian groups showed a highe r degree of differentiation both from each other and from the German p opulation cluster. The observed differences reflect the geographical d istances between populations. The importance of the subunit systems of the BXIII coagulation factor and alpha-2-HS-glycoprotein in the ethno geographic differentiation of populations is emphasized.