COMPATIBILITY STUDY OF METHOTREXATE WITH PVC BAGS AFTER REPACKAGING INTO 2 TYPES OF INFUSION ADMIXTURES

Authors
BENAJI B DINE T GOUDALIEZ F LUYCKX M BRUNET C MALLEVAIS ML GRESSIER B CAZIN M CAZIN JC
Citation
B. Benaji et al., COMPATIBILITY STUDY OF METHOTREXATE WITH PVC BAGS AFTER REPACKAGING INTO 2 TYPES OF INFUSION ADMIXTURES, International journal of pharmaceutics, 105(1), 1994, pp. 83-87
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
105
Issue
1
Year of publication
1994
Pages
83 - 87
Database
ISI
SICI code
0378-5173(1994)105:1<83:CSOMWP>2.0.ZU;2-Z
Abstract
The stability and compatibility of methotrexate in admixtures for cont inuous intravenous infusion using PVC bags and administration set were studied. Methotrexate was reconstituted and diluted to 4.5 mg/ml for infusion in PVC containers, and to 0.225 and 24 mg/ml for storage in P VC bags containing 5% dextrose or 0.9% sodium chloride injections. Adm ixtures were stored at + 4-degrees-C and with protection from light fo r 30 days. Analyses were performed by HPLC. In every case, no signific ant drug loss was observed during storage or simulated infusions using PVC infusion bags and administration sets.