Ma. Faouzi et al., LEACHING OF DIETHYLHEXYL PHTHALATE FROM PVC BAGS INTO INTRAVENOUS TENIPOSIDE SOLUTION, International journal of pharmaceutics, 105(1), 1994, pp. 89-93
The stability of teniposide in various diluents and polyvinyl chloride
bags was determined, and the extent of leaching of di(2-ethylhexyl) p
hthalate (DEHP) from PVC bags caused by the teniposide formulation was
measured. No significant drug loss was observed during simulated infu
sions (n = 4) for 1 h using PVC infusion bags and administration sets.
No significant difference was found between infusion-solutions (5% gl
ucose or 0.9% NaCl). To minimize patient exposure to DEHP, teniposide
solutions may be stored in a glass or polyolefin container and deliver
ed through polyethylene-lined i.v. administration sets. If PVC bags ar
e used for preparing teniposide solutions, the injections must be used
immediately after preparation or stored 4-5 h at +4-degrees-C.