P-GUANIDINOBENZOYL-[HYP(3), THI(5),D-TIC(7), OIC(8)]BRADYKININ IS ALMOST COMPLETELY DEVOID OF THE AGONIST EFFECT OF HOE140 ON THE ENDOTHELIUM-FREE FEMORAL-ARTERY OF SHEEP

Authors
THURIEAU C FELETOU M CANET E FAUCHERE JL
Citation
C. Thurieau et al., P-GUANIDINOBENZOYL-[HYP(3), THI(5),D-TIC(7), OIC(8)]BRADYKININ IS ALMOST COMPLETELY DEVOID OF THE AGONIST EFFECT OF HOE140 ON THE ENDOTHELIUM-FREE FEMORAL-ARTERY OF SHEEP, Bioorganic & medicinal chemistry letters, 4(6), 1994, pp. 781-784
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
6
Year of publication
1994
Pages
781 - 784
Database
ISI
SICI code
0960-894X(1994)4:6<781:PTOIA>2.0.ZU;2-K
Abstract
Substitution of the N-terminal arginine of [D-Arg0, Hyp3, Thi5, D-Tic7 , Oic8]bradykinin ( HOE140) by 4-guanidinobenzoic acid results in an a nalogue with at least the same antagonistic potency on rabbit smooth m uscle preparations but with considerable reduction of its agonistic pr operties on the endothelium-free femoral artery of sheep.