QSAR STUDY OF ORTHO-PHENYLPHENOL LEUKOTRIENE B4 RECEPTOR ANTAGONISTS

Authors
WIKEL JH SOFIA MJ SAUSSY DL BEMIS KG
Citation
Jh. Wikel et al., QSAR STUDY OF ORTHO-PHENYLPHENOL LEUKOTRIENE B4 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(6), 1994, pp. 795-800
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
6
Year of publication
1994
Pages
795 - 800
Database
ISI
SICI code
0960-894X(1994)4:6<795:QSOOLB>2.0.ZU;2-V
Abstract
QSAR models for a series of o-phenylphenol LTB4 receptor antagonist ha ve been developed with regression analysis. These models related speci fic features, electronic, size and shape, of the substituent with biol ogical activity. The models have predictive value and may be useful in assisting future synthetic direction within this series of compounds.