SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SC-53228, A LEUKOTRIENE B4 RECEPTOR ANTAGONIST WITH HIGH INTRINSIC POTENCY AND SELECTIVITY

Authors
DJURIC SW DOCTER SH YU SS SPANGLER D TSAI BS ANGLIN CP GAGINELLA TS KACHUR JF KEITH RH MAZIASZ TJ VILLANIPRICE D RAO TS WALSH RE WIDOMSKI DL FRETLAND DJ
Citation
Sw. Djuric et al., SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SC-53228, A LEUKOTRIENE B4 RECEPTOR ANTAGONIST WITH HIGH INTRINSIC POTENCY AND SELECTIVITY, Bioorganic & medicinal chemistry letters, 4(6), 1994, pp. 811-816
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
6
Year of publication
1994
Pages
811 - 816
Database
ISI
SICI code
0960-894X(1994)4:6<811:SAPAOS>2.0.ZU;2-N
Abstract
The Structure Activity Relationship (SAR) studies leading to the ident ification of a novel high potency Leukotriene B4 receptor antagonist S C-53228 are delineated. This compound shows excelled pharmacodynamic e fficacy in animal models of inflammatory disease.