2-ARYL-1-AZABICYCLO[2.2.2]OCTANES AS NOVEL NONPEPTIDE SUBSTANCE-P ANTAGONISTS

Authors
LOWE JA EWING FE SNIDER RM LONGO KP CONSTANTINE JW LEBEL WS WOODY HA BORDNER J
Citation
Ja. Lowe et al., 2-ARYL-1-AZABICYCLO[2.2.2]OCTANES AS NOVEL NONPEPTIDE SUBSTANCE-P ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(6), 1994, pp. 839-842
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
6
Year of publication
1994
Pages
839 - 842
Database
ISI
SICI code
0960-894X(1994)4:6<839:2ANNSA>2.0.ZU;2-B
Abstract
The synthesis and SAR of a series of 2-aryl-1-azabicyclo[2.2.2]octanes structurally related to the nonpeptide substance P antagonists CP-96, 345 and CP-99,994 arc described. The novel SAR observed at the 2-posit ion in these derivatives represents a hybrid between that seen in the two previous series.