COMPATIBILITY OF U-67590A STERILE SOLUTION WITH NORMAL SALINE, DEXTROSE SOLUTION, AND SOLITA-T NO-3 WITH OR WITHOUT AMINOPHYLLINE INJECTABLE

The compatibility of U-67590A sterile solution (SS) with three drip fl uids (normal saline, 5% dextrose solution, and Solita-T No. 3) and Neo phylline(R) (an aminophylline injectable) was studied. The entire volu me or U-67590A SS in an ampoule was transferred into each of the drip fluid containers (500 mL fill). The container was laid under fluoresce nt light (ca. 1,200 lux) at room temperature. The physical appearance (color and precipitates), pH, U-67590A concentration, and degradation impurity levels were examined for 24 hr. The chemical and physical sta bility of U-67590A in these drip fluids was adequate enough so that an y one of the three can be used for U-67590A administration. However, t he stability was reduced when aminophylline co-existed in the admixtur es because of increased pH levels. In this case, the stability depende d on the strength of U-67590A SS added and the drip fluid used. In ter ms of chemical stability, Solita-T No. 3 was most favorable when admir ed with aminophylline injectable. The fastest degradation was observed in normal saline containing aminophylline. This instability was cause d by the higher ionic strength. Dextrose did not seem to affect the st ability of U-67590A significantly. The Solita-T No. 3 admixture had th e lowest pH, thereby overcoming the negative effect of ionic strength and giving the highest stability among the three admixtures. The stabi lity of U-67590A in direct admixture with Neophylline(R) also depended on the strength of U-67590A; the stability increased with strength of U-67590A.