THE ROLE OF MOISTURE AND GAP AIR-PRESSURE IN THE FORMATION OF SPHERICAL GRANULES BY ROTARY PROCESSING

Citation
Lsc. Wan et al., THE ROLE OF MOISTURE AND GAP AIR-PRESSURE IN THE FORMATION OF SPHERICAL GRANULES BY ROTARY PROCESSING, Drug development and industrial pharmacy, 20(16), 1994, pp. 2551-2561
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
03639045
Volume
20
Issue
16
Year of publication
1994
Pages
2551 - 2561
Database
ISI
SICI code
0363-9045(1994)20:16<2551:TROMAG>2.0.ZU;2-6
Abstract
Spheroids are usually produced by a multi-step extrusion-spheronizatio n process. The single-step production of spheroids may be carried out in a rotoprocessor. The use of feed materials in powder form requires an adaptation of the spheronizer machinery. This study investigates th e formation and growth of spheroids and the changes in the spheroid mo isture content in a single-step agglomeration-spheronization method. T here was a rapid increase in size and formfactor values when spheroids started to form and grow from the powder mix. Although there was a co ntinual and considerable loss of moisture with time, this did not have an appreciable effect on spheroid size and shape after the spheroid f ormation stage as the spheroid structure had already been determined. Spheroid size increased with higher liquid spray rates. The use of hig her gap air pressures resulted in a greater rate of moisture loss and the production of smaller spheroids.