Lsc. Wan et al., THE ROLE OF MOISTURE AND GAP AIR-PRESSURE IN THE FORMATION OF SPHERICAL GRANULES BY ROTARY PROCESSING, Drug development and industrial pharmacy, 20(16), 1994, pp. 2551-2561
Spheroids are usually produced by a multi-step extrusion-spheronizatio
n process. The single-step production of spheroids may be carried out
in a rotoprocessor. The use of feed materials in powder form requires
an adaptation of the spheronizer machinery. This study investigates th
e formation and growth of spheroids and the changes in the spheroid mo
isture content in a single-step agglomeration-spheronization method. T
here was a rapid increase in size and formfactor values when spheroids
started to form and grow from the powder mix. Although there was a co
ntinual and considerable loss of moisture with time, this did not have
an appreciable effect on spheroid size and shape after the spheroid f
ormation stage as the spheroid structure had already been determined.
Spheroid size increased with higher liquid spray rates. The use of hig
her gap air pressures resulted in a greater rate of moisture loss and
the production of smaller spheroids.