NATURAL POLYMER HYDROPHILIC MATRIX - INFLUENCING DRUG-RELEASE FACTORS

Authors
RIZK S DURU C GAUDY D JACOB M COLOMBO P MASSIMO G
Citation
S. Rizk et al., NATURAL POLYMER HYDROPHILIC MATRIX - INFLUENCING DRUG-RELEASE FACTORS, Drug development and industrial pharmacy, 20(16), 1994, pp. 2563-2574
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
20
Issue
16
Year of publication
1994
Pages
2563 - 2574
Database
ISI
SICI code
0363-9045(1994)20:16<2563:NPHM-I>2.0.ZU;2-P
Abstract
In porous hydrophilic polymeric systems, two phenomena control the rel ease of drugs the water uptake and polymer swelling. Directly compress ed hydrophilic matrices were prepared with scleroglucan as gelling age nt. A principal components analysis enables the authors to study the c orrelation between the above phenomena and the dissolution behavior in order to interpret the effect of polymer concentration excipient solu bility and compression force on the drug release.