ASSOCIATION OF APOLIPOPROTEIN-E ALLELE EPSILON-4 WITH LATE-ONSET SPORADIC ALZHEIMERS-DISEASE

Authors
LUCOTTE G VISVIKIS S LEININGERMULER B DAVID F BERRICHE S REVEILLEAU S COUDERC R BABRON MC AGUILLON D SIEST G
Citation
G. Lucotte et al., ASSOCIATION OF APOLIPOPROTEIN-E ALLELE EPSILON-4 WITH LATE-ONSET SPORADIC ALZHEIMERS-DISEASE, American journal of medical genetics, 54(3), 1994, pp. 286-288
Citations number
22
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of medical genetics → ACNP
ISSN journal
01487299
Volume
54
Issue
3
Year of publication
1994
Pages
286 - 288
Database
ISI
SICI code
0148-7299(1994)54:3<286:AOAAEW>2.0.ZU;2-A
Abstract
Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associate d with late-onset sporadic Alzheimer's disease (AD) in French patients . The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clini cal expression of AD. (C) 1994 Wiley-Liss,Inc.