A SINGLE LINKAGE GROUP COMPRISING 11 POLYMORPHIC DNA MARKERS ON RAT CHROMOSOME-3

Authors
ZHA H REMMERS EF DU Y GOLDMUNTZ EA MATHERN P ZHANG H CASH JM CROFFORD LJ WILDER RL
Citation
H. Zha et al., A SINGLE LINKAGE GROUP COMPRISING 11 POLYMORPHIC DNA MARKERS ON RAT CHROMOSOME-3, Mammalian genome, 5(9), 1994, pp. 538-541
Citations number
12
Categorie Soggetti
Biology,"Genetics & Heredity","Biothechnology & Applied Migrobiology
Journal title
Mammalian genome → ACNP
ISSN journal
09388990
Volume
5
Issue
9
Year of publication
1994
Pages
538 - 541
Database
ISI
SICI code
0938-8990(1994)5:9<538:ASLGC1>2.0.ZU;2-#
Abstract
Eleven polymorphic DNA markers were mapped to rat Chromosome (Chr) 3 b y linkage analysis of F-2 progeny of F344/N and LEW/N rat strains. The markers, including seven genes and four anonymous loci, formed a sing le linkage group covering approximately 112 cM with the following orde r: Ptgs1 (prostaglandin G/H synthase I)-D3Arb178-Scn2a (sodium channel , type II, alpha-polypeptide)-D3Arb1-Cat (catalase)-Bdnf (brain-derive d neurotrophic factor)-D3Arb219-D3Arb2-Sus2 (seminal vesicle secretion II protein)-Sdc4 (ryudocan/syndecan4)-Stnl (statin-like protein). Eig ht of these markers were analyzed for polymorphisms in 14 additional i nbred rat strains. Three to five alleles were detected for each marker , suggesting that they are highly polymorphic and useful for genetic m apping studies with inbred rat strains. Chromosomal syntenic conservat ion among rats, mice and humans is also discussed.