NEUROLOGY AND NEUROPATHOLOGY OF HEMORRHAG IC-FEVER WITH RENAL SYNDROME

Direct observation of 160 patients (in acute period of the disease and within 10-year followup), examination of 220 case records and neuroan atomic study of 37 cases were performed to study nervous system in pat ients suffered from hemorrhagic fever with renal syndrome. Severe, per sistent and widespread neurological symptoms were described as well as mnestic-intellectual disturbances. The latter were defined as encepha lopathic syndrome with pronounced neurological deficit. The anatomic s tudy (light and electron microscopy) revealed dystrophic alterations o f nervous tissue as well as viruses and virus-like substance in many r egions of the brain. The authors suppose that direct viral action was the reason for tissue damages of nervous system. The viral penetration through hematoencephalic barrier was not exluded either.