ANTIOXIDANTS IN THE TREATMENT OF SCHIZOPH RENIA (CORRECTION OF LIPID-PEROXIDATION)

It was established in the course of 186 schizophrenic patients' examin ation that intensification of lipid peroxidation (LP) took place In re lapses of the disease. It was manifested either in increase of blood s erum levels of both malonic dialdehyde and diene conjugates, or in dec rease of erythrocytes' resistance to LP mediated hemolysis. Alteration s in indices of either spontaneous or induced chemoluminescence were r evealed too. LP indices were lower by the end of the treatment in hosp ital, but remained significantly higher than normal values. Applicatio n of antioxidants in combined treatment of schizophrenic patients prom oted decrease of LP activity as well as improvement in mental state of patients. LP activity was high in the remission too. Determination of LP indices may have prognostic importance.