Lm. Bui et al., ZINC STATUS AND INTERLEUKIN-1 BETA-INDUCED ALTERATIONS IN MINERAL METABOLISM IN RATS, Proceedings of the Society for Experimental Biology and Medicine, 206(4), 1994, pp. 438-444
Changes in zinc (Zn) metabolism and interleukin-1 beta (IL-1 beta) rel
ease occur as part of the physiological response to tissue injury and
trauma. In the present study, the influence of Zn status on the respon
se to continuous low-dose IL-1 beta administration was evaluated. Rats
were fed 50 mu g Zn/g (adequate zinc; AZn) or 5 mu g Zn/g (marginal z
inc; MZn) diets for 14 days. On day 15, rats were infused via osmotic
minipumps, with IL-1 beta (2.3 ng/hr) or saline (control, C) and eutha
nized 1, 3, or 7 days later. In the AZn rats, IL-1 beta infusion resul
ted in increased plasma copper (Cu) concentrations and ceruloplasmin (
Cp) activity, and decreased iron (Fe) concentrations throughout the 7d
period. These effects were most pronounced on dl and d3. A similar tr
end was observed in the MZn rats, but IL-1 beta-induced increases in p
lasma Cu and Cp activity were less than in the AZn fed rats. In MZn an
d AZn IL-1 beta infused rats, plasma Zn was decreased on Day 1, and Da
y 3, respectively, compared with their respective controls. AZn IL-1 b
eta-infused rats were characterized by high liver Fe, Zn, and metallot
hionein (MT) concentrations on Day 1; by Day 7, only MT concentrations
remained elevated. Liver MnSOD activity was 13%-29% higher in both th
e AZn- and MZn-IL-1 beta-infused rats than their respective controls o
n Day 3 and Day 7, with most significant increase observed on Day 7. T
hese data show that Zn status can influence the response to low-dose I
L-1 beta; this influence of 70 should be considered when IL-1 beta