O. Uzun et al., EFFICACY OF A 3-DAY COURSE OF AZITHROMYCIN IN THE TREATMENT OF COMMUNITY-ACQUIRED PNEUMOCOCCAL PNEUMONIA - PRELIMINARY-REPORT, Journal of chemotherapy, 6(1), 1994, pp. 53-57
Azithromycin is an azalide antibiotic with activity against many of th
e respiratory pathogens and with marked tissue affinity. In a prospect
ive study, the efficacy of a short course of azithromycin was evaluate
d in 25 patients with community-acquired pneumococcal pneumonia. Gram-
positive diplococci were abundant in the sputum smears of all patients
, and Streptococcus pneumoniae was isolated in the sputum cultures of
15; one patient had pneumococcal bacteremia, as well. Azithromycin was
administered at a single dose of 1,000 mg on day 1, and 500 mg on sub
sequent days for a total of three days in 19 patients, five days in fo
ur patients, two and four days in one patient each. Defervescence occu
rred within 24 hours after the first dose. The overall clinical cure a
nd bacteriologic eradication rates were 96% and 93%, respectively. One
patient with pneumococcal bacteremia failed to respond and died in re
spiratory failure. Side-effects were encountered in three (12%) patien
ts. In conclusion, three-day therapy with a total azithromycin dose of
1,500 mg seems effective and safe in patients with community-acquired
pneumococcal pneumonia and no underlying pulmonary condition.