THEONEGRAMIDE, AN ANTIFUNGAL GLYCOPEPTIDE FROM THE PHILIPPINE LITHISTID SPONGE THEONELLA-SWINHOEI

Theonegramide (2) is an antifungal glycopeptide consisting of arabinos e joined to a bicyclic dodecapeptide that contains the unusual amino a cids beta-hydroxyasparagine, isoserine, alpha-aminoadipic acid, -amino -4-hydroxy-6-methyl-8-phenylocta-5,7-dienoic acid, and the same histid inoalanine moiety previously observed in theonellamide F (1). The stru cture of theonegramide (2) was elucidated by analysis of spectral data and its absolute configuration was determined by GC-MS analysis using a chiral column packing.