Ti. Wallow et Bm. Novak, HIGHLY EFFICIENT AND ACCELERATED SUZUKI ARYL COUPLINGS MEDIATED BY PHOSPHINE-FREE PALLADIUM SOURCES, Journal of organic chemistry, 59(17), 1994, pp. 5034-5037
Suzuki aryl cross-couplings employing aryl bromides and aryl iodides p
roceed under mild conditions (65 degrees C) with high efficiency (subs
trate-to-catalyst ratios in excess of 500) in the presence of phosphin
e-free palladium catalysts derived from palladium acetate, Pd-2(dba)(3
).C6H6 (dba = dibenzylideneacetone), and [(eta(3)-C3H5)PdCl](2). Phosp
hine inhibition is shown to play a key role in limiting catalytic effi
ciency; qualitative comparison studies show that the phosphine-free sy
stems are 1-2 orders of magnitude more active than phosphine-supported
catalytic systems. Pd[P(Ph)(3)](4) proved to be the least active of t
he catalytic species screened. The phosphine-free methodology appears
to be generally applicable; cross-couplings of aryl iodides yielding b
iaryls 6 and 7 proceed without noticeable steric or electronic effects
. Cross-couplings employing aryl bromides are insensitive to electroni
c effects in the synthesis of 6 but are slowed by steric hindrance in
the synthesis of 7. Acceleration of cross-coupling is observed in the
presence of polar cosolvents and at high pH.