This paper presents the results of a cost-benefit analysis conducted f
or pregnancy prevention treatment with four hormonal methods of contra
ception using a managed-care viewpoint. The therapies analyzed are med
roxy-progesterone acetate injection (Depo-Provera(R)), levonorgestrel
subdermal implants (Norplant(R)), progestogen-only oral tablets (Nor-Q
D(R)), and combination progestogen/estrogen oral tablets (Ortho-Novum(
R) 7/7/7). Cost and benefits associated with the use of therapies are
identified and analyzed based on the cost per patient-day of effective
pregnancy prevention. The analysis demonstrates that all four methods
have a positive net benefit, with Depo-Provera having the highest net
benefit. This information can provide decision makers within a pharma
cy and therapeutics committee of a managed-care organization the frame
work on which to base formulary decisions.