PERIPHERAL CD4- GAMMA-DELTA T-CELL LYMPHOMA - A CASE-REPORT WITH MULTIPARAMETER ANALYSES( CD8)

A 72-year-old Japanese man presented with CD4+ T cell receptor (TCR) g amma delta T cell lymphoma involving bilateral cervical lymph nodes. N o involvement by tumor was observed in the liver, spleen, nasal cavity , or bone marrow throughout his clinical course. Although the tumor ad equately responded to chemotherapy and irradiation, he relapsed with s hort remission and a slowly aggressive clinical course, and died 24 mo nths after onset. Simultaneous expression of TCR gamma delta with othe r T-cell antigens on the lymphoma cells was analyzed by 3-color flow c ytometry (3-FCM), and showed a unique phenotype CD3+ CD4+ CD8- CD7- CD 5+ CD2++ TCR alpha beta (WT31)- beta F1- TCR gamma delta 1 (11F2)+ TCR delta 1+. Cytogenetic analysis showed 79-81 and structural abnormalit ies consisting of del(1)(p11) and i(17)(q10). But no abnormality was i dentified in chromosome 7. DNA analysis revealed gene rearrangements o f TCR gamma and delta, while a nongerm line band in TCR beta was aberr antly seen. These observations suggest a new subtype of gamma delta T- cell lymphoma, which is characterized by CD4 positivity and by a clini cal course not as aggressive as other predominant subtypes. Copyright (C) 1996 by W.B Saunders Company