SYNTHESIS AND ANTIVIRAL ACTIVITY EVALUATION OF SOME AMINOADAMANTANE DERIVATIVES

The synthesis of some spiro[cyclopropane-1,2'-adamantan]-2-amines and methanamines and some spiro[pyrrolidine-2,2'-adamantanes] is described . The title compounds were evaluated against a wide range of viruses ( influenza A, influenza B, parainfluenza 3, RSV, HSV-1, TK-HSV-1, HSV-2 , vaccinia, vesicular stomatitis, polio 1, coxsackie B4, sindbis, seml iki forest, Reo 1, HTV-1, and HTV-2), and some of them (compounds 6b, 6c, 9a, 16a, 16b, and 17) inhibited the cytopathicity of influenza A v irus at a concentration significantly lower than that of amantadine an d also significantly lower than the concentrations at which they prove d cytotoxic to the host cells. None of the new aminoadamantane derivat ives was active against influenza B virus or any of the other viruses tested, which points to their specificity as anti-influenza A virus ag ents.