GLOMERULOID HEMANGIOMA - A CUTANEOUS MARKER OF POEMS SYNDROME

Glomeruloid hemangioma is a histologically distinctive cutaneous heman gioma that recently has been associated with POEMS syndrome. We report a further case in which POEMS syndrome was signaled by multiple erupt ive angiomas of the glomeruloid type. Histopathology showed multiple d ilated vascular spaces containing a conglomerate of capillaries result ing in a structure resembling renal glomeruli. Eosinophilic globules, probably representing immunoglobulins, were found within the cytoplasm of some endothelial and stromal cells. The finding of focal histologi c features of tufted angioma (angioblastoma) in the same lesion sugges ts that a spectrum of hemangiomatous lesions may be seen in POEMS synd rome. Alternatively, glomeruloid hemangioma may represent a reactive e ndothelial proliferation rather than a neoplastic lesion.