2 CASES OF T(1-16)(P11-P11) IN MULTIPLE-MYELOMA - CONFIRMATION BY CHROMOSOME PAINTING

Authors
FLACTIF M LAI JL ZANDECKI M BERNARDI F TRILLOT N BAUTERS F FACON T
Citation
M. Flactif et al., 2 CASES OF T(1-16)(P11-P11) IN MULTIPLE-MYELOMA - CONFIRMATION BY CHROMOSOME PAINTING, Cancer genetics and cytogenetics, 76(1), 1994, pp. 10-14
Citations number
11
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
76
Issue
1
Year of publication
1994
Pages
10 - 14
Database
ISI
SICI code
0165-4608(1994)76:1<10:2COTIM>2.0.ZU;2-J
Abstract
Two patients with multiple myeloma and an unbalanced translocation, t( 1;16) (p11;p11), are reported. The fluorescence in situ hybridization (FISH) technique was used in one patient to confirm the translocation. To our knowledge, t(1;16)(p36;q13) and t(1;16)(q21;p13), but not t(1; 16)(p11;p11), had been reported previously in multiple myeloma. Our re sults suggest that FISH is useful to characterize structural abnormali ties and identify marker chromosomes in multiple myeloma where analysi s with conventional cytogenetics is often difficult.