A 45-year-old, healthy, well-trained man climbed within 12 hours from
300 m above sea level to a shelter at 2500 m in the Tyrolean Alps. Dur
ing the following 3 days he undertook ski tours to the surrounding mou
ntains up to 3356 m. On the 4th day he suddenly suffered from headache
, coughing and very severe dyspnoea even at rest, accompanied by loss
of appetite and the feeling of suffocation. The following day he was r
escued by a helicopter and taken to hospital. At the time of admission
the patient was severely hypoxaemic (capillary PO2 = 25.7 mmHg), and
the chest X-ray revealed signs of bilateral alveolar pulmonary edema l
ocalised predominantly in the right lung. High-altitude pulmonary edem
a (HAPE) was diagnosed because of the typical clinical course. Pulmona
ry gas exchange normalised within hours, and complete restitution was
achieved within 2 days. The chest X-ray was normal on the 4th day afte
r admission. HAPE is a non-cardiogenic pulmonary edema which develops
in healthy individuals usually above 3000 m. Among the predisposing fa
ctors are rapid ascent, severe physical effort, diminished hypoxic ven
tilatory response and abnormal fluid balance. The treatment of choice
is descent to a lower altitude, administration of oxygen and of nifedi
pine and expiratory positive airway pressure.