PREDICTION OF FUTURE SERUM CONCENTRATIONS WITH BAYESIAN FITTED PHARMACOKINETIC MODELS - RESULTS WITH DATA COLLECTED BY NURSES VERSUS TRAINED PHARMACY RESIDENTS

Recording the times of dosage administration and serum sampling by tra ined personnel resulted in significantly greater adherence to the prot ocol of therapeutic drug monitoring and in significantly greater preci sion in the achievement of desired serum concentration goals of aminog lycoside therapy than when relatively untrained personnel recorded it as a comparatively unemphasized part of their job. This was true even when only data of peak and trough serum concentrations were used. This study demonstrates that thoughtful data collection by appropriately t rained nursing, pharmacy, or other clinical personnel is an essential part of therapeutic drug monitoring and plays a significant role in th e optimal individualization of drug dosage regimens for patient care.