THYROID-CANCER IN BYELARUS POST-CHERNOBYL - IMPROVED DETECTION OR INCREASED INCIDENCE

There is debate on whether the reported increase in the number of case s of childhood thyroid cancer in Belarus is real and attributable to r adiation released following the Chernobyl nuclear accident, or rather an artefact due to incorrect histological diagnosis, more complete cas e reporting and mass screening of children after the accident We have scrutinised the histological slides of 120 (75%) of the 160 cases repo rted among children aged up to 15 years to the Belarus tumour registry from 1986 to 1992 and examined time trends and geographical patterns in incidence and tumour characteristics. Incidence based on reported c ases increased from 0.041 per 100.000 in 1986 to 2.548 in 1992. Carcin oma was confirmed in 94% of reviewed tumours. Except for one medullary carcinoma all histologies were of the papillary type. Most of the tum ours had spread beyond the organ capsule and measured over 10 mm in di ameter. There was a weak and statistically non-significant trend (p = 0.19) towards smaller tumours in the later years. The proportion of ca ses with lymphnode or distant metastasis remained unchanged. Incidence based on histologically confirmed cases was highest adjacent and to t he west and north of Chernobyl, matching best estimates of iodine-131 contamination. Our data thus strongly suggest that the observed increa se is real but more data are needed in order to assess the impact of m ass screening and to clarify the possible association with radiation r eleased at Chernobyl in 1986.