SYNTHESIS OF CHELATING MOLECULES AS AGENTS FOR MAGNETIC-RESONANCE-IMAGING .2. SYNTHESIS AND COMPLEXING PROPERTIES OF N-ACRYLOYL DIETHYL IMINODIACETATE COPOLYMERS

The synthesis of a monomer with diethyl iminodiacetate groups was inve stigated in order to obtain complexing copolymers. Copolymers of N-acr yloyl diethyl iminodiacetate with acrylamide and acrylic acid were syn thetized by a radical mechanism using 2,2'-azobisisobutyronitrile (AIB N) as initiator in dioxane at 80-degrees-C. The compositions of the co polymers were established by H-1 nuclear magnetic resonance (NMR) spec troscopy. The reactivity ratios were determined by both Fineman-Ross a nd Kelen-Tudos methods. The chelating ability of the synthetized copol ymers was investigated with Eu-152.