LABELED COMPOUNDS OF INTEREST AS ANTITUMOR AGENTS .4. DEUTERATION ANDTRITIATION OF A NITROIMIDAZOLE-CARBORANE DESIGNED FOR BNCT

Authors
SCOBIE M BEW SP THREADGILL MD
Citation
M. Scobie et al., LABELED COMPOUNDS OF INTEREST AS ANTITUMOR AGENTS .4. DEUTERATION ANDTRITIATION OF A NITROIMIDAZOLE-CARBORANE DESIGNED FOR BNCT, Journal of labelled compounds & radiopharmaceuticals, 34(9), 1994, pp. 881-885
Citations number
16
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
34
Issue
9
Year of publication
1994
Pages
881 - 885
Database
ISI
SICI code
0362-4803(1994)34:9<881:LCOIAA>2.0.ZU;2-1
Abstract
Quenching the anion generated from a 2-(omega-carboranylalkyl)dithiane with (H2O)-H-2 at -78 degrees C and at 0 degrees C introduced deuteri um exclusively at C-2 of the carborane. Extension of this model reacti on to a bioreductively-targetted carborane allowed the synthesis of 2- [H-2]- and 2-[H-3]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.