A CONVENIENT METHOD FOR CYANATION OF AROMATIC IODO COMPOUNDS

Authors
CARR RM CABLE KM WELLS GN SUTHERLAND DR
Citation
Rm. Carr et al., A CONVENIENT METHOD FOR CYANATION OF AROMATIC IODO COMPOUNDS, Journal of labelled compounds & radiopharmaceuticals, 34(9), 1994, pp. 887-897
Citations number
14
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
34
Issue
9
Year of publication
1994
Pages
887 - 897
Database
ISI
SICI code
0362-4803(1994)34:9<887:ACMFCO>2.0.ZU;2-A
Abstract
A variety of [C-13]-labelled aromatic nitriles have been prepared in g ood yield from iodoaromatic substrates. Cyanation was achieved by reac tion of aryl iodides with a mixture of potassium [C-13]cyanide and cop per (I) iodide in an aprotic solvent at high temperature. The use of p re-prepared carbon-labelled copper (I) cyanide was therefore obviated.