SUCRALFATE SUSPENSION AS A TREATMENT OF RECURRENT APHTHOUS STOMATITIS

Design. A prospective randomized, double-blind, placebo-controlled, cr oss-over clinical trial. Setting. A university hospital. Subjects. Twe nty-one patients with symptomatic recurrent aphtous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divide d into three groups. Intervention. In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a p lacebo for 2 years. Results. After 2 years of follow-up, sucralfate wa s found to be superior to both placebo and antacid (P < 0.001) with re gard to duration of pain, reduction of the healing period, response ti me to first treatment and duration of remission. Conclusion. Sucralfat e suspension should be added to the armament of treatment modalities o f RAS.