SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 3-DEOXY-DL-PRUMYCIN ANALOGS

Authors
CONSTANTINOUKOKOTOU V KOKOTOS G CHRYSAYITOKOUSBALIDES M COULADOUROS EA GEORGIADIS MP
Citation
V. Constantinoukokotou et al., SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 3-DEOXY-DL-PRUMYCIN ANALOGS, Liebigs Annalen der Chemie, (8), 1994, pp. 847-850
Citations number
12
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen der Chemie → ACNP
ISSN journal
01702041
Issue
8
Year of publication
1994
Pages
847 - 850
Database
ISI
SICI code
0170-2041(1994):8<847:SAAAO3>2.0.ZU;2-6
Abstract
A number of 3-deoxy-DL-prumycin analogues containing one or more amino acid moieties were synthesized. Key intermediate 2 afforded ester ana logues by coupling with H-D- or L-Ala-OH, while intermediates 6 and 9 afforded amide analogues by coupling with H-D-Ala-D-Ala-OH, H-D-Ala-OH , 2-amino-4,4-dichlorobutanoic acid and acetic acid. The antifungal ac tivity of the analogues against various phytopathogenic fungi was meas ured.