TOPICAL TESTOSTERONE IN THE TREATMENT OF VULVAR LICHEN-SCLEROSUS

Objectives: Comparison between 2% testosterone propionate and petrolat um ointment in the treatment of vulvar lichen sclerosus in a randomize d, double-blind, controlled clinical study. Methods: Fifty-eight conse cutive patients with histologically confirmed vulvar lichen sclerosus were enrolled. They underwent a 1-year period of topical treatment wit h either medication, with clinical evaluations of symptoms and gross a ppearance at 2-month intervals, followed by histological evaluation at the end of the treatment period. Statistical analysis was performed a ccording to the chi-squared test and the Student-Newman-Keuls test. Re sults: A substantial improvement in symptoms was achieved in 20 (66.6% ) patients in the testosterone group and in 21 (75%) patients in the p lacebo group. No statistical differences were observed between the two groups. Gross changes were observed in a few cases and no case demons trated histologic modifications. Conclusions: Petrolatum ointment is a s effective as 2% testosterone in the treatment of vulvar lichen scler osus.