We have investigated 195 pre-menopausal women undergoing third molar e
xtractions, in a prospective study, to assess the influence of the day
of the menstrual cycle on the incidence of postoperative nausea or vo
miting. In the 95 patients taking the oral contraceptive pill the inci
dence of postoperative nausea or vomiting was higher on days 9 to 15 o
f the menstrual cycle (P < 0.05) than on days one to eight and days 16
to the end of cycle. In the 100 patients who were not taking the oral
contraceptive pill the incidence of postoperative nausea or vomiting
was not higher on days 9 to 15. The strongest predictor for postoperat
ive nausea or vomiting in our study was a previous episode of postoper
ative nausea or vomiting (P < 0.005). Patients with a tendency to moti
on sickness did not have a higher incidence of postoperative nausea or
vomiting.