INTERLEUKIN-3 AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR-RECEPTOR SIGNAL-TRANSDUCTION

Authors
MUI ALF MIYAJIMA A
Citation
Alf. Mui et A. Miyajima, INTERLEUKIN-3 AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR-RECEPTOR SIGNAL-TRANSDUCTION, Proceedings of the Society for Experimental Biology and Medicine, 206(3), 1994, pp. 284-288
Citations number
55
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Proceedings of the Society for Experimental Biology and Medicine → ACNP
ISSN journal
00379727
Volume
206
Issue
3
Year of publication
1994
Pages
284 - 288
Database
ISI
SICI code
0037-9727(1994)206:3<284:IAGCF>2.0.ZU;2-7
Abstract
The cytokines, interleukin-3 (IL-3) and granulocyte-macrophage colony- stimulating factor (GM CSF), share many similar activities on cells of the hemopoietic system. Cloning of the receptors for IL-3 and GM-CSF revealed that these two cytokines utilize receptors consisting of a li gand-specific alpha unit and a beta subunit which is shared. Neither s ubunit contains intrinsic tyrosine kinase activity, but deletion analy sis of the beta subunit cytoplasmic domain has defined certain regions which are important for signal transduction.