G. Frutos et al., APPLICATION OF THE STATISTICAL MULTIVARIATE-ANALYSIS TO THE RELEASE CHARACTERIZATION OF MATRIX TABLETS, Drug development and industrial pharmacy, 20(17), 1994, pp. 2685-2694
The introduction of new sustances that can be used as excipient in con
trolled release formulations constitutes a relevant step in obtaining
simple, reliable and accurate methods which makes it possible to repro
duce the controlled release of drugs. Therefore, the aim of this work
is to study the influence of different technological variables on the
modulation of the release of the active principle compressed with a ne
w excipient to formulate matrix tablets. A Poliamyde 12 was used as th
e rate-controlling polymer in controlled-release tablet formulation. D
ifferent techniques of multivariate analysis have been applied to the
release characterization of matrix tablets studied.