SURVIVAL AND TRANSMITTER EXPRESSION OF RAT CHOLINERGIC MEDIAL SEPTAL NEURONS DESPITE REMOVAL OF HIPPOCAMPUS IN THE EARLY POSTNATAL-PERIOD

Authors
PLASCHKE M KASPER EM NAUMANN T FROTSCHER M
Citation
M. Plaschke et al., SURVIVAL AND TRANSMITTER EXPRESSION OF RAT CHOLINERGIC MEDIAL SEPTAL NEURONS DESPITE REMOVAL OF HIPPOCAMPUS IN THE EARLY POSTNATAL-PERIOD, Neuroscience letters, 176(2), 1994, pp. 243-246
Citations number
29
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
176
Issue
2
Year of publication
1994
Pages
243 - 246
Database
ISI
SICI code
0304-3940(1994)176:2<243:SATEOR>2.0.ZU;2-Z
Abstract
It has been shown that target-derived neurotrophins are not necessary for the survival of septohippocampal cholinergic neurons in adult rats . In this study, we have removed the hippocampus in early postnatal ra ts by unilateral excitotoxic N-methyl-D-aspartate lesions at postnatal days 5, 10 and 20. At postnatal day 70, numerous cholinergic neurons (60% of controls) were present in the medial septum on the lesioned si de. This suggests that there is only a limited influence of target-der ived neurotrophic factors to these cells also in development.