AN IMPROVED METHOD FOR CHIRAL OXAZABOROLIDINE-CATALYZED REDUCTION OF 4-CHROMANONE ANALOGS AND MK-0499

Authors
SHI YJ CAI DW DOLLING UH DOUGLAS AW TSCHAEN DM VERHOEVEN TR
Citation
Yj. Shi et al., AN IMPROVED METHOD FOR CHIRAL OXAZABOROLIDINE-CATALYZED REDUCTION OF 4-CHROMANONE ANALOGS AND MK-0499, Tetrahedron letters, 35(35), 1994, pp. 6409-6412
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
35
Year of publication
1994
Pages
6409 - 6412
Database
ISI
SICI code
0040-4039(1994)35:35<6409:AIMFCO>2.0.ZU;2-Z
Abstract
Addition of isopropanol to the stoichiometric reduction of ketones 4-8 using oxazborolidine-borane complex 3 or the oxazaborolidine-catalyze d reduction of 4-chromanone analogs (1, 7-9) enhances the enantioselec tivity of the reduction.